Global Hip Dysplasia Registry
About GHDR
The Global Hip Dysplasia Registry (GHDR) is a comprehensive, prospective international registry for all infants and children that are diagnosed with or have risk factors for developmental dysplasia of the hip (DDH).
The goal of this initiative is to identify best practices and standardize treatment and management strategies in order to optimize clinical and functional outcomes for patients with DDH.
GHDR
A Global Registry for Developmental Dysplasia of the Hip.
5 CONTINENTS
30 CENTRES
7.7 K PATIENTS
7 COUNTRIES
Registry Objectives:
Develop a longitudinal, prospective registry for infants and children diagnosed across the spectrum of DDH.
Develop targeted hypothesis-testing studies (i.e., RCTs) performed within the larger registry context.
Hip Condition:
Developmental Dysplasia of the Hip (DDH)
Our Work
2023
Action Plan:
Fully onboard South American centres and begin recruiting patients
Launch the first Randomized Control Trial (RCT) from within the registry
Achievements:
Onboarded first centres in Africa
Awarded a CIHR Grant for the first Randomized Control Trial (RCT) from within the registry
2024
Achievements:
GHDR surpasses 6,700 patients enrolled
Recruitment has now begun at 2 sites for Brace vs Observation RCT
4 additional sites have gone through onboarding training
2022
Achievements:
GHDR changes its name from the International Hip Dysplasia Registry to the Global Hip Dysplasia Registry
GHDR surpasses 5,300 patients enrolled, with 1,000 patients enrolled from BC Children’s Hospital
2021
Achievements:
Patient recruitment increases after the slowdown from the COVID-19 pandemic
Reached a recruitment milestone of 4000 patients worldwide
2 study publications from participating investigators
Under-represented regions are targeted for registry participation
Began onboarding of first sites in South America
Our Publications
Johnson, Luke G.1,2; Bortolussi-Courval, Sara1,3; Chehil, Anjuli4; Schaeffer, Emily K.5,6; Pawliuk, Colleen7; Wilson, David R.2,5; Mulpuri, Kishore5,6,7. Application of statistical shape modeling to the human hip joint: a scoping review. JBI Evidence Synthesis 21(3):p 533-583, March 2023. | DOI: 10.11124/JBIES-22-00175
Grzybowski, Georgia BSc*; Bliven, Emily MEng*; Wu, Luke BSc†; Schaeffer, Emily K. PhD‡,§; Gibbard, Marissa BSc†; Zomar, Bryn O. PhD‡,§; Casagrande Cesconetto, Alice MEng*; Mundy, Claire BSc∥; Mulpuri, Kishore MBBS, MS, MHSc, FRCSC‡,§; International Hip Dysplasia Registry Knowledge Translation Advisory Board. Caregiver Experiences Using Orthotic Treatment Options for Developmental Dysplasia of the Hip in Children. Journal of Pediatric Orthopaedics 43(2):p 105-110, February 2023. | DOI: 10.1097/BPO.0000000000002312
Upasani, Vidyadhar V. MD*; Bomar, James D. MPH*; Fitzgerald, Ryan E. MD*; Schupper, Alexander J. MD*; Kelley, Simon P. MBChB, PhD, FRCS†; International Hip Dysplasia Registry. Prolonged Brace Treatment Does Not Result in Improved Acetabular Indices in Infantile Dislocated Hips. Journal of Pediatric Orthopaedics 42(5):p e409-e413, May/June 2022. | DOI: 10.1097/BPO.0000000000002110
Schaeffer EK, Ponton E, Sankar WN, Kim HKW, Kelley SP, Cundy PJ, Price CT, Clarke NMP, Wedge JH, Mulpuri K; International Hip Dysplasia (IHD) Study Group. Interobserver and Intraobserver Reliability in the Salter Classification of Avascular Necrosis of the Femoral Head in Developmental Dysplasia of the Hip. J Pediatr Orthop. 2022 Jan 1;42(1):e59-e64. DOI: 10.1097/BPO.0000000000001979.
Li J, Aroojis A, Mulpuri K, Shea KG, Schaeffer EK. Development of a DDH Care Pathway for India: A Study Methodology to Guide Similar Efforts in Other Countries and for Other Conditions. Indian J Orthop. October 2021. [Epub ahead of print] DOI: 10.1007/s43465-021-00534-y.
Pinto D, Aroojis A, Shah H, Patwardhan S, Venkatadass K, Sahu C, Schaeffer E, Mulpuri K. Demographic and Practice Variability Amongst Indian Centres in a Multicentre Prospective Observational Study on Developmental Dysplasia of the Hip. Indian J Orthop. September 2021. DOI: 10.1007/s43465-021-00516-0.
Zomar BO, Mulpuri K, Schaeffer EK. Examining the Short-Term Natural History of Developmental Dysplasia of the Hip in Infancy: A Systematic Review. Indian J Orthop. September 2021. DOI: 10.1007/s43465-021-00510-6.
Mulpuri K, Schaeffer EK, Price CT. Global Collaborations in Developmental Dysplasia of the Hip. Indian J Orthop. September 2021. DOI: 10.1007/s43465-021-00504-4.
Gibbard M, Zivkovic I, Jivraj B, Schaeffer E, Robillard JM, Mulpuri K. International Hip Dysplasia Registry Knowledge Translation Advisory Board. A Global Survey of Patient and Caregiver Experiences Throughout Care for Developmental Dysplasia of the Hip. J Pediatr Orthop B. July 2021. DOI: 10.1097/BPO.0000000000001813.
Harper P, Joseph BM, Clarke NMP, Herrera-Soto J, Sankar WN, Schaeffer EK, Mulpuri K, Aarvold A, IHDI Study Group. Even Experts Can Be Fooled: Reliability of Clinical Examination for Diagnosing Hip Dislocations in Newborns. J Pediatr Orthop. June 2020. DOI: 10.1097/BPO.0000000000001602.
Striano B, Schaeffer EK, Matheney TH, Upasani VV, Price CT, Mulpuri K, Sankar WN, International Hip Dysplasia Institute. Ultrasound Characteristics of Clinically Dislocated But Reducible Hips with DDH. J Pediatr Orthop. October 2019. DOI: 10.1097/BPO.0000000000001048
Sankar WN, Gornitzky AL, Clarke NM, Herrera-Soto JA, Kelley SP, Matheney T, Mulpuri K, Schaeffer EK, Upasani VV, Williams N, Price CT. Closed reduction for developmental dysplasia of the hip: early-term results from a prospective, multicenter cohort. J Pediatr Orthop. March 2019. DOI: 10.1097/BPO.0000000000000895.
Aarvold A, Schaeffer EK, Kelley S, Clarke NMP, Herrera-Soto JA, Price CT, Mulpuri K, IHDI Study Group. Management of irreducible hip dislocations in infants with developmental dysplasia of the hip diagnosed below 6 months of age. J Pediatr Orthop. January 2018. DOI: 10.1097/BPO.0000000000001205.
Gornitzky AL, Schaeffer EK, IHDI Study Group, Sankar WN. Pavlik harness disease revisited: does prolonged treatment of a dislocated hip in a harness adversely affect acetabular morphology? J Pediatr Orthop. 2018;38(6):297-304.
Schaeffer EK, Mulpuri K. Developmental dysplasia of the hip: addressing evidence gaps with a multicentre prospective international study. The Medical Journal of Australia. May 2018. DOI: 10.5694/mja18.00154
Walton S, Schaeffer E, Mulpuri K, Cundy P, Williams N. Evaluating the role of prereduction hip traction in the management of infants and children with developmental dysplasia of the hip (DDH): protocol for a systematic review and planned meta-analysis. BMJ Open. January 2018. http://dx.doi.org/10.1136/bmjopen-2017-019599.
Upasani VV, Bomar JD, Matheney TH, Sankar WN, Mulpuri K, Price CT, Moseley CF, Kelley SP, Narayanan U, Clarke NM, Wedge JH, Castañeda P, Kasser JR, Foster BK, Herrera-Soto JA, Cundy PJ, Williams N, Mubarak SJ. Evaluation of brace treatment for infant hip dislocation in a prospective cohort: Defining the success rate and variables associated with failure. J Bone Joint Surg Am. July 2016. DOI: 10.2106/JBJS.15.01018.
Schaeffer EK, Price CT, Mulpuri K, IHDI Study Group. Developmental Dysplasia of the Hip and laterality: The importance of graded severity of the contralateral hip. Orthopaedic Proceedings. December 2016. DOI:/10.1302/1358-992X.98BSUPP_21.COA2016-040.
Mulpuri K, Schaeffer EK, Andrade J, Sankar WN, Williams N, Matheny TH, Mubarak SJ, Cundy PJ, Price CT, IHDI Study Group. What risk factors and characteristics are associated with late-presenting dislocations of the hip in infants? Clin Orthop Relat Res. May 2016. DOI: 10.1007/s11999-015-4668-0.
Mulpuri K, Schaeffer EK, Kelley SP, Castaneda P, Clarke NM, Herrera-Soto JA, Upasani V, Narayanan UG, Price CT, IHDI Study Group. What is the impact of center variability in a multicenter international prospective observational study on developmental dysplasia of the hip? Clin Orthop Relat Res. May 2016. DOIi: 10.1007/s11999-016-4746-y.
Narayanan U, Mulpuri K, Sankar WN, Clarke NMP, Hosalkar H, Price CT. Reliability of a new radiographic classification for developmental dysplasia of the hip. J Pediatr Orthop. July 2015. DOI:10.1097/BPO.0000000000000318.